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CLET / SLET · regional rarity · sub-specialty

Stem cell transplant: vision after the limbus is destroyed.

Limbal stem cells (at the edge of the cornea) constantly regenerate the corneal surface. When destroyed by chemical burns, severe scarring, or aniridia syndrome, the cornea opacifies and a transplant won't last without first restoring the stem cell population. CLET (cultivated) and SLET (simple limbal epithelial transplantation) bring the surface back to life.

Limbal Stem Cell Transplantation with Dr. Ahmed Shaarawy, Shaarawy Cornea Clinic

Why choose us

International standard. Regional access.

One of few regional centers performing CLET

Cultivated Limbal Epithelial Transplantation requires a specialized lab. Few centers in the Arab region perform it; we run the protocol in collaboration with a tissue lab in Cairo.

SLET in a single OR session

The SLET technique (Sangwan, India 2012) gives a CLET-like result without the lab, small biopsy from your healthy eye, distributed onto a bandage contact lens, glued to the affected eye.

Right candidate selection

Stem cell transplant only works after detailed evaluation. We screen with impression cytology, anterior segment OCT, and detailed history before committing.

Two-stage rehabilitation when needed

Severe cases need stem cell transplant first, then corneal transplant 6-12 months later once the surface is healed. We plan the full sequence upfront.

Real patient experience

An eye-surface injury: stem cells first, then the cornea

Fatma was injured in an accident that damaged the surface of her eye. Dr. Ahmed Shaarawy first transplanted stem cells onto the corneal surface, waited for it to settle, and then did the corneal transplant.

"Even my family didn't expect a result like this."

★★★★★
Dr. Shaarawy explains

Why stem cells come before the corneal transplant

A patient from Iraq had lost his sight for more than ten years after blast fragments destroyed the surface of his eye. Dr. Ahmed Shaarawy first transplanted stem cells from his son onto the corneal surface, waited for it to settle, and then did the corneal transplant.

"When you plant something in the ground, you first have to make sure the ground is healthy and will let the plant grow."

★★★★★

Procedures & pricing

Transparent USD pricing.

Final cost is set after clinical examination. Local-currency equivalents available on request. Insurance reports issued for international patients.

ProcedureBest forFrom (USD)
SLET (Simple Limbal Epithelial Transplantation)Single-step, autologous, no lab$2,000 - $3,500
CLET (Cultivated Limbal Epithelial Transplantation)Lab-cultured, larger area coverage$2,500 - $4,000
Combined CLET + later corneal transplantTwo-stage rehab for severe cases$5,500 - $8,500
تجربة مريض حقيقية

Watch a real patient's experience with Dr. Ahmed Shaarawy

A real patient tells the whole story, from diagnosis to corneal renewal after ocular stem-cell transplantation.

Common questions

Frequently asked.

Is this the same as the stem cell treatments I've read about for other eye diseases?
No. What we transplant are limbal stem cells, the cells at the edge of the cornea that keep renewing the surface of the eye. The transplant rebuilds the corneal surface after burns and injuries, and it does not treat any other part of the eye. Stem cell treatments advertised for other eye diseases are a different thing entirely, and the clinic does not offer them.
Who is a candidate?
Patients with limbal stem cell deficiency (LSCD), most commonly from chemical or thermal burns (especially alkali burns), severe contact lens-related damage, Stevens-Johnson syndrome sequelae, aniridia syndrome, and certain genetic conditions.
How is SLET different from CLET?
Both transplant limbal stem cells from your healthy eye to the diseased one. SLET is single-stage (biopsy + transplant in one OR session, no lab). CLET grows the cells in a lab over 2-3 weeks first, then transplants the cultivated sheet. CLET covers a larger area; SLET is simpler and equally effective for moderate cases.
What if both eyes are affected?
Allogeneic (donor) stem cells from a relative or eye bank are an option, but require lifelong immunosuppression. We screen carefully and discuss the trade-offs in detail. Some bilateral cases are best managed with keratoprosthesis (artificial cornea) instead.
What's the success rate?
In the paper that first described SLET, all six eyes treated for unilateral total limbal stem cell deficiency after ocular burns had a completely epithelialised, avascular and stable corneal surface by six weeks, maintained over a mean follow-up of about nine months (Sangwan VS, Basu S, MacNeil S, Balasubramanian D, Br J Ophthalmol. 2012;96(7):931-934, PMID 22328817). That is a six-eye series with short follow-up, not a five-year success rate. Bilateral cases are considerably more variable. Long-term success depends heavily on patient selection and post-op management, and the visual outcome depends on whether a subsequent corneal transplant is also needed.

Book your consultation

Pick a day and time. The first visit is an eye exam with Dr. Ahmed Shaarawy, who tells you which option suits your eyes.

Chemical burn or LSCD case? Send the details.

Stem cell candidacy requires careful evaluation, send your full ocular history, recent OCT and impression cytology if available, and photos of the eye. We'll respond within 24 hours with whether SLET / CLET / keratoprosthesis is the right path and the all-in cost.

Medical references

  1. Sangwan VS, Basu S, MacNeil S, Balasubramanian D (PMID 22328817). "Simple limbal epithelial transplantation (SLET): a novel surgical technique for the treatment of unilateral limbal stem cell deficiency." Br J Ophthalmol. 2012;96(7):931-934.
  2. Dr. Ahmed Shaarawy: 20+ years of corneal and refractive surgery, Devers Eye Institute fellowship (Portland, Oregon), two surgical techniques published in the AAO video series. The figures on this page come from the published literature, not from this clinic's own patients.
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